Best thiazide diuretic for hypertension.

Diuretic treatment of resistant hypertension.

In patients with hypertension resistant to three or four drugs including a thiazide diuretic substitution of frusemide for the thiazide, or the addition of spironolactone, produced significant reductions in blood pressure and body weight. The response did not depend on the presence of overt fluid retention, renal impairment, or the use of antihypertensive drugs of high potency. Women had larger...

Module 2: Rethinking the role of thiazide-type diuretics in the management of hypertension: which diuretic is best?

Evaluation of thiazide diuretic use as preferred therapy in uncomplicated essential hypertension patients

UNLABELLED Thiazide diuretics are effective antihypertensive medications shown to reduce the risk of cardiovascular events and stroke. Despite being the preferred choice for uncomplicated essential hypertension, thiazide diuretics continue to be underutilized. METHODS Uncomplicated essential hypertension patients taking a single antihypertensive medication were evaluated upon enrollment, diag...

Lack of effect of beta-blocker on flat dose response to thiazide in hypertension: efficacy of low dose thiazide combined with beta-blocker.

Increasing the dose of a thiazide diuretic used alone in patients with essential hypertension has little further effect on blood pressure but increases the deleterious metabolic consequences of the diuretic. The effect of a beta-blocker on this flat dose response is not known. In two randomised crossover studies the effect of 12.5 mg, 25 mg, and 50 mg hydrochlorothiazide combined with 400 mg ac...

Drug notes Bendroflumethiazide

COPYRIGHT © 2013 JOHN WILEY & SONS Introduction Hypertension is common in people with diabetes. While ACE-inhibitors (ACE-Is) and angiotensin II receptor antagonists remain first-line antihypertensive agents, adequate blood pressure (BP) reduction may require two or three drugs including thiazide-like diuretics. Chlorthalidone was the diuretic used in several large diabetes hypertension studies...